This is a project I have been working on for a while.
Grateful to David Tuller and the local hosts: Vera Kindlon (Assoc trustee), Audrey Lodge, Ashling O’Leary & Michelle Dinn, Sarah Warde, Orla Ní Chomhraí (Assoc trustee) & Ruth Flood @roothflud . 👍
@tomkindlon
Interesting! Great to see a study confirm anecdotal/survey evidence. Though worth noting that the sample size was too small to make any direct call on CFS: only one person had CFS before getting covid.
"28.2% reported experiencing brain fog, who were generally older (mean brain fog 35.7 ± 11.9 years vs. 32.8 ± 11.6 years, p < 0.0001) and more likely to be female (OR = 1.2, p < 0.001)"
"Comorbidities included #longCOVID-19 (OR = 3.8, p < 0.0001), #concussions (OR = 2.4, p < 0.0001), and higher #migraine disability assessment scores (MIDAS) (+34.1%, all p < 0.0001)."
"At this point, we can mostly admit we “know we don’t know much” about PASC in older adults. Part of the reason for the lack of knowledge is the general limitations in the literature on #PASC"
“(Contd) The FMT group showed a decrease in ISI score (p<0.0001), PSQI (p<0.0001), GAD-7 (p=0.0019), ESS (p=0.0057) and blood cortisol concentration (p=0.035) from baseline to week 12, but there was no significant change in the control group."
Study of 11 #LongCovid vs 34 healthy patients transcriptome at day 14 of Covid infection. "We identified 26 upregulated genes in patients experiencing long COVID. Dysregulated pathways including complement and fibrinolysis pathways and IL-7 upregulation."
“A range of conditions including Guillain-Barré syndrome/cognitive deficit/insomnia/anxiety disorder/encephalitis/ischaemic stroke/mood disorder exhibited a pronounced increase in long-term risk”
"A new piece in The Conversation shows just how problematic it is when poorly done biopsychosocial studies claim to have documented that cognitive and/or behavioral therapies are effective—and when these questionable findings are published in high-impact journals. The headline of the article: “Success in treating persistent pain now offers hope for those with #LongCOVID.”
My response to that: “No it doesn’t.”"
It certainly is easy to fix a problem when you ignore 95% of what's happening and reduce it to simple fatigue and/or pain (which are basically the same thing anyhow, according to assorted quacks from the University of Otago.)
In 2022 Carl Jreidini wrote about taking the lead himself in his long Covid care and asked for "more collaborative, open-minded relationship with healthcare professionals".
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Karen Hargrave has written a response, “ #Longcovid: I’d rather have a well researched and well informed doctor than “become my own physician”, sharing her own and her husbands' experience with long Covid and ME/CFS, spending hours doing research and being more informed than the clinicians.”
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Post summarises this paper:
New Publication by Solve Ramsay Grant Researcher Dr. Deborah Duricka Studies Efficacy of Stellate Ganglion Block in Reducing Post-Exertional Malaise and Improving Sleep and Neurological Function
"Welcome to the 107th Emerge Australia Research Digest, where we delve into recent research and media releases shaping our understanding of ME/CFS and #LongCOVID..."
The summaries are also available in audio form at link
“The idea of rehabilitation will have to be completely rethought for this illness” – Qualitative results of an online survey on patients’ experiences with inpatient rehabilitation for #postCOVID19 condition ( #longCOVID )
'(50 %) reported that their state of health deteriorated, mainly because of strength or endurance training'
'learning strategies to avoid deterioration in their state of health due to overexertion, the so-called pacing, should be the core treatment goal for patients affected by PEM.'
"22.5% did not recover by 90 days post infection". "Recovery within 3 months was less likely in women and those with preexisting cardiovascular disease"
"No significant multivariable-adjusted associations [for non-recovery] were observed for age, educational attainment, smoking history, obesity, diabetes, chronic kidney disease, asthma, chronic obstructive pulmonary disease, or elevated depressive symptoms. Results were similar for reinfections"
"Passive transfer of IgG from patients to mice led to increased sensitivity & pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance & coordination, reflecting donor-reported dizziness"