tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

US research:

Sex differences and immune correlates of Long COVID development, persistence, and resolution

https://www.biorxiv.org/content/10.1101/2024.06.18.599612v1

"males […] had widespread increases in TGF-β signaling during acute infection in proliferating NK cells. (contd)”

@longcovid

@covid19 @auscovid19

1/

tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/

“(Contd) Females […] demonstrated increased expression of XIST, an RNA gene implicated in autoimmunity, and increased IL1 signaling in monocytes"

"this study describes multiple innate and adaptive immune correlates of LC, some of which differ by sex"

@longcovid
@covid19 @novid @auscovid19

flavia_feijo_epi ,
@flavia_feijo_epi@med-mastodon.com avatar
tomkindlon , to NoVID
@tomkindlon@disabled.social avatar

"We've Hit Peak Denial. Here's Why We Can't Turn Away From Reality"

https://www.scientificamerican.com/article/weve-hit-peak-denial-heres-why-we-cant-turn-away-from-reality/

Opinion piece asking why we overlook bad things, "especially in this scientific and technological age, when we’ve never been more capable of understanding and addressing them".


@longcovid

@covid19
@novid @novid

1/

tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/

They urge to stop enabling the denial with doubling "down on our duty to know, to speak up, and to remember".

& are mentioned

====
Hashtags:
@longcovid

@covid19
@novid @novid
@auscovid19

anne_twain ,
@anne_twain@theblower.au avatar

@tomkindlon @longcovid @covid19 @novid @novid There's a paywall on this article.

tomkindlon , to AusCOVID19 group
@tomkindlon@disabled.social avatar

The Organization for Economic Cooperation & Development has published a paper, The impacts of across OECD countries, which looks the burden of Long including how it may impact productivity & the labour force.

https://www.oecd.org/health/the-impacts-of-long-covid-across-oecd-countries-8bd08383-en.htm

Hashtags:
@longcovid

@covid19
@novid
@auscovid19

1/

tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/
"The economic and social welfare costs of are dramatic: Even excluding the direct costs of health care, long is likely costing OECD countries as much as $864 billion - $1.04 trillion USD per year due to reductions in quality of life and labour force participation."

Hashtags:
@longcovid

@covid19
@novid @novid
@auscovid19

tomkindlon , to AusCOVID19 group
@tomkindlon@disabled.social avatar
tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/
"We found that PCC* participants with poorer sleep quality had worse cognitive performance in some domains (verbal and visual memory and processing speed), with a moderating effect on quality of life, cognitive reserve, and everyday memory failure."

*post-COVID-19 condition

@longcovid @covid19 @novid @novid @auscovid19

tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

Vocational rehabilitation for Long Covid: a roadmap for recovery

https://t.co/oqCQPoxwt7

"Long Covid and similar energy-limiting illnesses cause a range of health problems which result in long-term sickness absence and long-term unemployment in an era of workforce shortage."

Hashtags:
@longcovid

@spoonies
1/

ALT
  • Reply
  • Loading...
  • tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    "(Contd) The variability of the condition and of employer attitudes, severity of impact on daily life and work, and the fluctuating nature of the condition pose the question of how to manage a sustained return to work."

    @longcovid @spoonies

    tomkindlon , to ChronicIllness group
    @tomkindlon@disabled.social avatar
    ALT
  • Reply
  • Loading...
  • tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    They gave blood and saliva samples at home or at a nearby lab.

    “The Pax LC trial is a historic contribution to the evolution of a new way of doing trials”

    "Traveling to each participant’s home would seem to be a pricey endeavor. But given its greater efficiency, the design of the PAX LC Trial has actually cut down on costs", Krumholz argues.

    Comment: The same issues arise with ME/CFS. I see Jarred Younger is doing one or more trials remotely

    @longcovid @mecfs @chronicillness @spoonies

    tomkindlon , to longcovid group
    @tomkindlon@disabled.social avatar
    ALT
  • Reply
  • Loading...
  • tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    "Utilizing our novel metabolic modeling method, GPMM [Genome-wide knockout analyses], we identified the key metabolic irregularities in patients with ME/CFS and Long COVID, notably the downregulation of the alanine and aspartate metabolism pathway, and the arginine and proline metabolism pathway."

    @longcovid @covid19 @mecfs

    tomkindlon , to longcovid group
    @tomkindlon@disabled.social avatar

    New German study

    Altered brain perfusion and oxygen levels relate to sleepiness and attention in

    Free full text:
    https://onlinelibrary.wiley.com/doi/10.1002/acn3.52121

    "our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"

    Hashtags:
    @longcovid

    @covid19

    1/

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    "(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."

    ========================
    Hashtags:
    @longcovid

    @covid19
    @novid @novid
    @auscovid19

    tomkindlon , to AusCOVID19 group
    @tomkindlon@disabled.social avatar

    ABC News (Australia): Too many children with are suffering in silence

    https://t.ly/SrKjj

    "One of the things that shocks Dr Scoullar most, though, is how many of her patients have struggled with other doctors,especially paediatricians”

    Hashtags:
    @longcovid @covid19 @novid @auscovid19

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    Drs “tell the parents of [], 'Just get them up and get them active' — & that's the advice that really exacerbates things." Because if a child who suffers from post-exertional malaise (PEM) is pushed beyond their capacity, they can deteriorate rapidly”

    @longcovid @covid19 @novid @auscovid19

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    3/

    “And for many people with long COVID and ME/CFS, exercise is a sure-fire way to provoke PEM [post-exertional malaise], which is why clinical guidelines in the US and UK advise doctors not to recommend it without strict supervision.”


    @longcovid @covid19 @novid @auscovid19 @mecfs@a.gup.pe

    tomkindlon , to NoVID
    @tomkindlon@disabled.social avatar

    From David Tuller DrPH

    “In a recent piece Betsy Ladyzhets [from The Sick Times] reports about problems with RECOVER based on documents obtained through the Freedom of Information Act. We talked the other day about her findings.”

    https://virology.ws/2024/06/13/trial-by-error-betsy-ladyzhets-on-problems-with-nihs-recover-initiative/

    @longcovid
    #LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
    #CovidBrain
    #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid

    1/

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    "Ladyzhets recently wrote a new article about RECOVER, published in The Sick Times
    as well as STAT, based on documents she received from NIH through the Freedom of Information Act. We spoke the other day about what she found out".

    #LongCovid
    @longcovid

    tomkindlon , to AusCOVID19 group
    @tomkindlon@disabled.social avatar

    Interesting German paper:

    Persistent symptoms & clinical findings in adults with post-acute sequelae of / syndrome in the second year after acute infection: population-based, nested case-control study

    https://www.medrxiv.org/content/10.1101/2024.05.22.24307659v1

    @longcovid


    @covid19 @novid @auscovid19

    1/

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/
    "This nested population-based case-control study demonstrates the majority of PCS cases do not recover in the second year of their illness, with patterns of reported symptoms remaining essentially similar, nonspecific & dominated by fatigue, exercise intolerance & cognitive complaints”

    Hashtags:
    @longcovid @covid19 @novid

    tomkindlon , to longcovid group
    @tomkindlon@disabled.social avatar

    New-ish US [Mayo Clinic] study:

    Pro Inflammatory Cytokines Profiles of Patients With Long Differ Between Variant Epochs

    Free:
    https://journals.sagepub.com/doi/10.1177/21501319241254751

    "When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch . (contd)"

    @longcovid

    @covid19

    1/

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    "(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."

    Hashtags:
    @longcovid

    @covid19
    @novid
    @auscovid19

    tomkindlon , to NoVID
    @tomkindlon@disabled.social avatar

    •First network meta-analysis of oral antiviral drugs effects on condition ( )

    •Early use of oral antiviral drugs in acute phase of has a protective effect against PCC

    •Nirmatrelvir-ritonavir may be a superior choice over molnupiravir on reducing risk of PCC

    Hashtags:
    @longcovid

    @covid19
    @novid

    1/

    ChiaraChiarel ,
    @ChiaraChiarel@piaille.fr avatar

    @tomkindlon @longcovid @covid19 @novid @auscovid19
    the link doesn't work 😕

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    @ChiaraChiarel

    Thanks for letting me know.

    There are brackets in the link which I think may confuse the software.
    This should work:
    https://t.ly/J3ivM

    @longcovid @covid19 @novid @auscovid19

    tomkindlon , to AusCOVID19 group
    @tomkindlon@disabled.social avatar
    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    4/
    "Participants described tracking health trajectories using wearables and other assistive devices including apps, [t]rackers and wireless activity and heart rate monitors to identify potential triggers and learn limits to inform strategies of pacing"

    @longcovid

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    5/

    "A notable feature of episodic disability in the context of Long COVID in this study was PESE or PEM which transcended physical, cognitive and mental-emotional dimensions, highlighting the ability of the framework to encompass critical features of disability experienced in the context of "

    Hashtags:
    @longcovid

    @covid19

    tomkindlon , to AusCOVID19 group
    @tomkindlon@disabled.social avatar
    nosat ,
    @nosat@liberdon.com avatar

    @SnerkRabbledauber @auscovid19 @covid19 @longcovid @novid @tomkindlon I hope you were this diligent about sources when you were told to take an experimental mystery injection a few years ago, if so, for sure you said no to it given the huge amount of horrible possible side effects that are listed directly by the manufacturer

    here is a few fun ones to consider

    SnerkRabbledauber ,
    @SnerkRabbledauber@mycrowd.ca avatar

    @nosat @auscovid19 @covid19 @longcovid @novid @tomkindlon

    Please don't bother sharing any more propagandized information.

    What do I mean by 'propagandized'? Well for one thing, the language (see 'rebranded flu') shows its purpose is not to describe, but rather to persuade.

    But even more importantly it does not present information in a useful form.

    Lists like this are useless without numbers. "Associated with" is a very, very broad term. Something that can occur in one out of a million cases can be said to be "associated with". Why don't you include car accidents on the list? Certainly at least one person that received a vaccination was also in a car accident, right? You could probably include shark attacks, and death by electrocution as well.

    See the problem? Without numbers, this list is useless.

  • All
  • Subscribed
  • Moderated
  • Favorites
  • random
  • test
  • worldmews
  • mews
  • All magazines