"The aim of this meta-analysis is to describe objective cognitive impairment in individuals with non-severe (mild or moderate) #SARSCoV2 cases in the post-acute stage of infection”
"Significantly increased Cho concentrations & decreased NAA/Cho were found in the CCS in the older #postCOVID19 subjects"
"may be related to the microstructural reorganization in the corpus callosum (also reported in diffusion measurements) rather than increased membrane turnover"
2/
"SARS-CoV-2 provokes persistent long-term brain metabolic changes on brain FDG PET in the selected population of patients with prolonged long COVID symptoms, without progressive worsening of the hypometabolisms."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
🇫🇷France: "People in France are being advised to self-isolate and wear masks, as an expert warns that “Covid is not gone”, and hospital cases continue to rise."
"52% increase week-on-week in hospital emergency visits for Covid-related issues, and 51% more consultations with SOS Médecins (1,507 between June 3 and 10)"
“Although studies have suggested many patients with long #COVID experience mental health challenges, we did not find that depressive symptoms prior to #SARSCoV2 infection were a major risk factor for long COVID”
🇮🇪 Ireland: ‘No visiting allowed’ at Irish hospital as ban issued over COVID and Norovirus outbreaks.
"This is in the interest of patient safety to protect your loved ones from exposure to COVID-19 & Norovirus, both of which are very prevalent in both the Hospital and community at the moment."
> "I just worry we're going to have a generation of kids who have a post-acute infection syndrome because we failed to protect them," Dr Putrino says, "because we told this lie over and over again that kids have nothing to worry about with COVID."
Persistent symptoms & clinical findings in adults with post-acute sequelae of #COVID19 / #postCOVID19 syndrome in the second year after acute infection: population-based, nested case-control study
2/
"This nested population-based case-control study demonstrates the majority of PCS cases do not recover in the second year of their illness, with patterns of reported symptoms remaining essentially similar, nonspecific & dominated by fatigue, exercise intolerance & cognitive complaints”
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
Mom was discharged, after she was stabilized, post day surgery/liver biopsy. She's going to rest in bed for rest of day when we get home. No strenuous physical activity for one week.
I had to ask almost all hospital medical staff, working with us today, to please put their masks on before coming near us. My handmarked mask helped with having no pushback on my mandatory mask-up request. Everyone I asked, stared at it, before grabbing masks & putting them on.
"Nine observational studies containing 866,066 patients were included, in which nirmatrelvir-ritonavir and molnupiravir were evaluated in eight and two studies respectively, with both drugs evaluated in one study. Pair-wise meta-analysis showed that early oral antiviral drugs reduced PCC risk (RR 0.77, 95% CI 0.68–0.88)."
4/
"Frequencies of new onset symptoms (in #PostCovid)
Among participants with #LongCOVID, the most common symptoms were post-exertional malaise (87%), fatigue (85%), brain fog (64%), dizziness or lightheadedness (62%), GI (59%), & palpitations (57%)."