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"SARS-CoV-2 provokes persistent long-term brain metabolic changes on brain FDG PET in the selected population of patients with prolonged long COVID symptoms, without progressive worsening of the hypometabolisms."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
“Although studies have suggested many patients with long #COVID experience mental health challenges, we did not find that depressive symptoms prior to #SARSCoV2 infection were a major risk factor for long COVID”
Persistent symptoms & clinical findings in adults with post-acute sequelae of #COVID19 / #postCOVID19 syndrome in the second year after acute infection: population-based, nested case-control study
"Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities & acute #COVID19 severity"
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
"Nine observational studies containing 866,066 patients were included, in which nirmatrelvir-ritonavir and molnupiravir were evaluated in eight and two studies respectively, with both drugs evaluated in one study. Pair-wise meta-analysis showed that early oral antiviral drugs reduced PCC risk (RR 0.77, 95% CI 0.68–0.88)."
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"Frequencies of new onset symptoms (in #PostCovid)
Among participants with #LongCOVID, the most common symptoms were post-exertional malaise (87%), fatigue (85%), brain fog (64%), dizziness or lightheadedness (62%), GI (59%), & palpitations (57%)."
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“People are developing new-onset disease as the result of an infection that they had 3 years ago,” says Ziyad Al-Aly, “It challenges the notion that these viruses are sort of self-contained or that after the acute phase, they become inconsequential.”
"And cumulatively, at three years, #longCOVID results in 91 disability-adjusted life years (DALY) per 1,000 people—DALYs being a measure of years lost to poor health or premature death. That is a higher incidence than either heart disease or cancer."
"Risks for post-acute sequelae declined over the years, but substantial residual risk remained in the third year, leading to 252.8 sequelae per 1,000 persons& 90.0 DALYs per 1,000 persons”
Long #Covid Support:
Research Involvement Consultancy
"We make it easy to involve people with #LongCovid in your research and help ensure your study is relevant, robust and keeps the patient voice at the centre."
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"Our research advisers are all people with Long Covid who are trained in Patient Involvement in Research and have practical experience of being involved in various studies. Book a slot in one of our regular scheduled online advice sessions."