"Significantly increased Cho concentrations & decreased NAA/Cho were found in the CCS in the older #postCOVID19 subjects"
"may be related to the microstructural reorganization in the corpus callosum (also reported in diffusion measurements) rather than increased membrane turnover"
2/
"SARS-CoV-2 provokes persistent long-term brain metabolic changes on brain FDG PET in the selected population of patients with prolonged long COVID symptoms, without progressive worsening of the hypometabolisms."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
"Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities & acute #COVID19 severity"
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
"In this study we clustered the transcriptome of #longCOVID patients into two distinct clusters & showed differences in innate and adaptive immune activation and pulmonary function between those clusters"
"Out of 350 [hospitalised] participants, 148 respondents (42.3%) recovered after 1 year of illness and 202 (57.7%) were still experiencing symptoms at the time of survey completion."
Comparing risk of post infection erectile dysfunction following SARS #Coronavirus 2 stratified by acute and long #COVID, hospitalization status, and vasopressor administration
"We found that patients with #longCOVID are at a higher risk of being diagnosed with ED than patients with only acute COVID, while there was no significantly increased risk for patients with more severe infection requiring hospitalization or vasopressors"
"(Contd) While pacing was an essential skill for many, it was a constant balancing act , that also came at a cost on their productivity, satisfaction, and overall feelings of fulfillment"
"A notable feature of episodic disability in the context of Long COVID in this study was PESE or PEM which transcended physical, cognitive and mental-emotional dimensions, highlighting the ability of the framework to encompass critical features of disability experienced in the context of #LongCOVID"
4/
"Frequencies of new onset symptoms (in #PostCovid)
Among participants with #LongCOVID, the most common symptoms were post-exertional malaise (87%), fatigue (85%), brain fog (64%), dizziness or lightheadedness (62%), GI (59%), & palpitations (57%)."
on a New York Times article on a new, major National Academies report, "Long-Term Health Effects of #COVID19: Disability & Function Following #SARSCoV2 Infection"
Democratic members of the #House select subcommittee on the coronavirus pandemic defended Dr. Anthony #Fauci ahead of Monday's hearing about the #US’ #COVID19#pandemic response, policies & transparency.
The representatives blasted #Republicans’ claims of Fauci’s involvement in starting [for real they had to say this] or covering up the pandemic as a “dangerous” & “cartoonish” narrative.
Dr #Fauci dismisses ‘preposterous’ allegations that he led #covid coverup
The infectious-disease expert said #Republicans have distorted emails between #scientists as they discussed whether a lab leak of the coronavirus was possible.
Fauci defended himself against claims that he orchestrated a coverup of the #coronavirus#pandemic’s origins, w/the fmr govt official rejecting some allegations as “simply preposterous.”
The prominent infectious-disease expert, who served as a snr leader at the #NIH for 4 decades, said #Republicans have distorted emails between himself & other scientists as they discussed whether a lab leak of the #coronavirus was possible.
“We spend our whole life trying to determine the causes of infectious diseases, & stop them to protect the American people,” #Fauci said, adding that he did not pressure colleagues to reach a conclusion about the origins of the virus.