tomkindlon , to AusCOVID19 group
@tomkindlon@disabled.social avatar

Interesting German #Covid paper:

Persistent symptoms & clinical findings in adults with post-acute sequelae of #COVID19 / #postCOVID19 syndrome in the second year after acute infection: population-based, nested case-control study

https://www.medrxiv.org/content/10.1101/2024.05.22.24307659v1

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID_19 #SARSCoV2 @novid #novid #auscovid19 @auscovid19

1/

tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/
"This nested population-based case-control study demonstrates the majority of PCS cases do not recover in the second year of their illness, with patterns of reported symptoms remaining essentially similar, nonspecific & dominated by fatigue, exercise intolerance & cognitive complaints”

Hashtags:
@longcovid @covid19 @novid

tomkindlon , to AusCOVID19 group
@tomkindlon@disabled.social avatar

Growth Differentiation Factor-15 Is Considered a Predictive Biomarker of in Non-hospitalized Patients

https://t.ly/eYkfB

"Elevated serum GDF-15 levels in acute phase of may act as a predictive biomarker with onset of long "

Sample sizes very small

Hashtags:

@longcovid

@covid19 @novid @auscovid19

tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

Circulating microaggregates as biomarkers for the

https://t.ly/0Eseu

"We report on a patient suffering from fatigue, post exertional malaise, pain & neurological symptoms as a consequence of the second infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood”

@longcovid

halcionandon , to longcovid group
@halcionandon@disabled.social avatar
halcionandon OP ,
@halcionandon@disabled.social avatar

@longcovid

https://www.ineteconomics.org/perspectives/blog/debilitating-a-generation-expert-warns-that-long-covid-may-eventually-affect-most-americans

‘The economy was sad so those in power slowly disabled and killed 8 billion people. That was the extinction of Homo Sapien Sapiens.’

julesbl ,
@julesbl@mastodon.me.uk avatar

@halcionandon @longcovid
People need to read this article and insist that governments do something about this, people should not have to suffer for years

tomkindlon , to AusCOVID19 group
@tomkindlon@disabled.social avatar

Plasma taurine level is linked to symptom burden & clinical outcomes in condition

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304522

"Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities & acute severity"

Hospitalised patients.

@longcovid
@covid19 @auscovid19

tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

New-ish US [Mayo Clinic] study:

Pro Inflammatory Cytokines Profiles of Patients With Long Differ Between Variant Epochs

Free:
https://journals.sagepub.com/doi/10.1177/21501319241254751

"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch . (contd)"

@longcovid

@covid19

1/

tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/

"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."

Hashtags:
@longcovid

@covid19
@novid
@auscovid19

toussaint , to random
@toussaint@newsie.social avatar
tomkindlon , to NoVID
@tomkindlon@disabled.social avatar

•First network meta-analysis of oral antiviral drugs effects on condition ( )

•Early use of oral antiviral drugs in acute phase of has a protective effect against PCC

•Nirmatrelvir-ritonavir may be a superior choice over molnupiravir on reducing risk of PCC

Hashtags:
@longcovid

@covid19
@novid

1/

tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/

"Nine observational studies containing 866,066 patients were included, in which nirmatrelvir-ritonavir and molnupiravir were evaluated in eight and two studies respectively, with both drugs evaluated in one study. Pair-wise meta-analysis showed that early oral antiviral drugs reduced PCC risk (RR 0.77, 95% CI 0.68–0.88)."

@longcovid

@novid
@auscovid19

tomkindlon OP ,
@tomkindlon@disabled.social avatar

‪3/‬
‪Early use of oral antiviral drugs and the risk of post COVID-19 syndrome: a systematic review and network meta-analysis‬

https://www.journalofinfection.com/article/S0163-4453(24)00124-5/fulltext‬

Hashtags:

@longcovid


@covid19 @novid @auscovid19

tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

From the Netherlands

Whole blood transcriptome in long patients reveals association with lung function and immune response

https://www.jacionline.org/article/S0091-6749(24)00566-9/fulltext

"In this study we clustered the transcriptome of patients into two distinct clusters & showed differences in innate and adaptive immune activation and pulmonary function between those clusters"

Hashtags:
@longcovid

@covid19

genXcrone , to longcovid group
@genXcrone@fandom.garden avatar

I have been on facebook. The things I have seen. Oh gods the things I have seen!

I'm playing here, but I've been on the precipice of an anxiety attack for about 45 minutes. In an autoimmune neurological illness group (so subtle, so not identifying) someone tested positive for Covid19 today and wanted our input on how it was with our flavor of illness and what we did.

Many of us got Paxlovid ASAP, thank fucking gods. But the rest. One of us rubbed horse dewormer on their feet. Several of us believed our doctors when they told us Paxlovid was only to decrease our current visible symptoms so didn't bother with it. One of us went to work and bragged about how they infected their entire small company. Very few of us know what airborne means. Most of us seem to get our news from FOX.

We are all going to die. This is me, one the sidewalk, with a sign. The world is ending. Deliberate ignorance rules.

The misinformation people will spread is unbelievable. I'm not so bothered about the horse dewormer (that came with valuable advice: get the topical, not the pills, FFS) because I assume most of us know that's bananas. But the Paxlovid stuff bothers me a lot.

Paxlovid is an antiviral and its purpose is to prevent the duplication and spread of viral particles, therefore hopefully preventing long-covid, hospitalization, and death. If you need to treat your stuffy head fever get some damn Nyquill and tell your doctor the same. (Preaching to the choir over here on Fedi and it feels so good.)

FOX is telling people that Paxlovid is a lie because it doesn't treat long-covid. It was never meant to. Long-covid is a compilation of a shit ton of damage and illnesses, none of which an antiviral would help with.

One of us in the group is in a snit now because she was wrong about all of her assertions and she got caught spreading the illness. Boo hoo, bitch.

@longcovid

tomkindlon , to NoVID
@tomkindlon@disabled.social avatar

A Holistic Analysis of Symptom Profiles among People with -19 in India: A Prospective 1-Year Follow-Up Study

https://www.sciencedirect.com/science/article/pii/S2213398424001490

"Out of 350 [hospitalised] participants, 148 respondents (42.3%) recovered after 1 year of illness and 202 (57.7%) were still experiencing symptoms at the time of survey completion."

Hashtags:
@longcovid

@covid19
@novid

tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

Comparing risk of post infection erectile dysfunction following SARS 2 stratified by acute and long , hospitalization status, and vasopressor administration

https://www.nature.com/articles/s41443-024-00913-7

"We found that patients with are at a higher risk of being diagnosed with ED than patients with only acute COVID, while there was no significantly increased risk for patients with more severe infection requiring hospitalization or vasopressors"

@longcovid

tomkindlon , to MECFS group
@tomkindlon@disabled.social avatar
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  • luckytran , to random
    @luckytran@med-mastodon.com avatar

    UPDATE: NY Governor Kathy Hochul said on CNN last night that she is considering a ban on masks.

    This is absolutely shameful! New York has suffered so much from COVID, and COVID is not over. We should be normalizing and depoliticizing masks, not banning them.

    Source: https://www.governor.ny.gov/news/icymi-audio-rush-transcript-governor-hochul-guest-cnn-laura-coates

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  • RebelGeek99 ,
    @RebelGeek99@mstdn.science avatar

    @luckytran truly shameful, thank you for staying on top of this stuff. The receipts will keep rolling in long after this election year, from healthcare staffing shortages to school absences to increasing health insurance premiums. isn't going anywhere, nor are the opportunistic pathogens (microbes, not politicians) taking advantage of the immune compromised status even mild infections may confer.

    tomkindlon , to AusCOVID19 group
    @tomkindlon@disabled.social avatar
    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/
    "While pacing and energy conservation was a necessary strategy, participants also spoke of the consequences that pacing had on their ability to work, engage in social activities (having to decline at last minute depending on energy level, uncertainty of crashes).

    Pacing sometimes involved prioritization and sacrifice, scaling back their activities to the bare minimum to manage their challenges with daily activities. (contd)"

    @longcovid

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    3/

    "(Contd) While pacing was an essential skill for many, it was a constant balancing act , that also came at a cost on their productivity, satisfaction, and overall feelings of fulfillment"

    @longcovid

    @covid19

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    4/
    "Participants described tracking health trajectories using wearables and other assistive devices including apps, [t]rackers and wireless activity and heart rate monitors to identify potential triggers and learn limits to inform strategies of pacing"

    @longcovid

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    5/

    "A notable feature of episodic disability in the context of Long COVID in this study was PESE or PEM which transcended physical, cognitive and mental-emotional dimensions, highlighting the ability of the framework to encompass critical features of disability experienced in the context of "

    Hashtags:
    @longcovid

    @covid19

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