Persistent symptoms & clinical findings in adults with post-acute sequelae of #COVID19 / #postCOVID19 syndrome in the second year after acute infection: population-based, nested case-control study
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"This nested population-based case-control study demonstrates the majority of PCS cases do not recover in the second year of their illness, with patterns of reported symptoms remaining essentially similar, nonspecific & dominated by fatigue, exercise intolerance & cognitive complaints”
"We report on a patient suffering from fatigue, post exertional malaise, pain & neurological symptoms as a consequence of the second #CoVID infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood”
"Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities & acute #COVID19 severity"
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
"Nine observational studies containing 866,066 patients were included, in which nirmatrelvir-ritonavir and molnupiravir were evaluated in eight and two studies respectively, with both drugs evaluated in one study. Pair-wise meta-analysis showed that early oral antiviral drugs reduced PCC risk (RR 0.77, 95% CI 0.68–0.88)."
"In this study we clustered the transcriptome of #longCOVID patients into two distinct clusters & showed differences in innate and adaptive immune activation and pulmonary function between those clusters"
I have been on facebook. The things I have seen. Oh gods the things I have seen!
I'm playing here, but I've been on the precipice of an anxiety attack for about 45 minutes. In an autoimmune neurological illness group (so subtle, so not identifying) someone tested positive for Covid19 today and wanted our input on how it was with our flavor of illness and what we did.
Many of us got Paxlovid ASAP, thank fucking gods. But the rest. One of us rubbed horse dewormer on their feet. Several of us believed our doctors when they told us Paxlovid was only to decrease our current visible symptoms so didn't bother with it. One of us went to work and bragged about how they infected their entire small company. Very few of us know what airborne means. Most of us seem to get our news from FOX.
We are all going to die. This is me, one the sidewalk, with a sign. The world is ending. Deliberate ignorance rules.
The misinformation people will spread is unbelievable. I'm not so bothered about the horse dewormer (that came with valuable advice: get the topical, not the pills, FFS) because I assume most of us know that's bananas. But the Paxlovid stuff bothers me a lot.
Paxlovid is an antiviral and its purpose is to prevent the duplication and spread of viral particles, therefore hopefully preventing long-covid, hospitalization, and death. If you need to treat your stuffy head fever get some damn Nyquill and tell your doctor the same. (Preaching to the choir over here on Fedi and it feels so good.)
FOX is telling people that Paxlovid is a lie because it doesn't treat long-covid. It was never meant to. Long-covid is a compilation of a shit ton of damage and illnesses, none of which an antiviral would help with.
One of us in the group is in a snit now because she was wrong about all of her assertions and she got caught spreading the illness. Boo hoo, bitch.
"Out of 350 [hospitalised] participants, 148 respondents (42.3%) recovered after 1 year of illness and 202 (57.7%) were still experiencing symptoms at the time of survey completion."
Comparing risk of post infection erectile dysfunction following SARS #Coronavirus 2 stratified by acute and long #COVID, hospitalization status, and vasopressor administration
"We found that patients with #longCOVID are at a higher risk of being diagnosed with ED than patients with only acute COVID, while there was no significantly increased risk for patients with more severe infection requiring hospitalization or vasopressors"
UPDATE: NY Governor Kathy Hochul said on CNN last night that she is considering a ban on masks.
This is absolutely shameful! New York has suffered so much from COVID, and COVID is not over. We should be normalizing and depoliticizing masks, not banning them.
@luckytran truly shameful, thank you for staying on top of this stuff. The receipts will keep rolling in long after this election year, from healthcare staffing shortages to school absences to increasing health insurance premiums. #LongCovid isn't going anywhere, nor are the opportunistic pathogens (microbes, not politicians) taking advantage of the immune compromised status even mild infections may confer.
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"While pacing and energy conservation was a necessary strategy, participants also spoke of the consequences that pacing had on their ability to work, engage in social activities (having to decline at last minute depending on energy level, uncertainty of crashes).
Pacing sometimes involved prioritization and sacrifice, scaling back their activities to the bare minimum to manage their challenges with daily activities. (contd)"
"(Contd) While pacing was an essential skill for many, it was a constant balancing act , that also came at a cost on their productivity, satisfaction, and overall feelings of fulfillment"
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"Participants described tracking health trajectories using wearables and other assistive devices including apps, [t]rackers and wireless activity and heart rate monitors to identify potential triggers and learn limits to inform strategies of pacing"
"A notable feature of episodic disability in the context of Long COVID in this study was PESE or PEM which transcended physical, cognitive and mental-emotional dimensions, highlighting the ability of the framework to encompass critical features of disability experienced in the context of #LongCOVID"