"Cognitive decline primarily manifested in individuals with severe COVID-19 during the initial year of infection, after which the rate of decline decelerated."
"The finding that patients with Long COVID show more comparable brain glucose metabolism to controls in the frontal cortex and basal ganglia subregions suggests that the pathophysiology of Long COVID fatigue may involve different biological systems beyond the central nervous system."
“MENSA offers a unique antibody snapshot to reveal the underlying viral drivers in #longCOVID thus demonstrating the persistence of SARS2 and reactivation of viral herpes in 60% of PASC patients."
"The largest proportion of Long COVID diagnoses occur among individuals with a first reinfection in the Delta epoch. The rate of Long COVID diagnoses has been increasing with each successive Omicron variant"
@tomkindlon@longcovid@covid19@novid@novid
Surely this study just shows most clinical data is from severe infection? I don't believe that my own data and from similar other cases would have ever been recorded, leading to a systemic bias...
Press release:
"Brain inflammation triggers muscle weakness after infections: In fruit flies and mice, scientists ID possible way to block muscle fatigue in #longCOVID, other diseases"
@tomkindlon@longcovid@mecfs@covid19 anecdotal account: I've been on both classes of drugs (JAKS inhibitor and IL-6 inhibitor) for rheumatoid arthritis and didn't experience much affect on the ME/CFS. Tbh the TNF-a inhibitor that I'm on now has done a lot more, at least for brain fog and very slow physical improvements.
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Extract:
“There is little evidence to suggest that poor fitness is the explanation for PEM – the characteristic worsening of symptoms following exertion – which in many cases does not involve physical
activity at all …”
Neurologically triggered PEM can occur without exceeding a heart rate threshold and is not the result of ventilatory anaerobic threshold problems.
Heart rate-based pacing is helpful for PEM triggered by physical activity, not for PEM triggered by cognitive, sensory, or emotional exertion. The only thing that works for my neuro PEM is timers and carefully calibrating the types of activities I do.
"In this work, an interventional method is developed to identify & remove the traveling microthrombi using targeted-magnetic microbubbles (TMMBs) & an interventional magnetic catheter”
New pre-print:
Circulating microclots are structurally associated with Neutrophil Extracellular Traps and their amounts are strongly elevated in long COVID patients
"Our study revealed that NETs may be a component of circulating FAM, suggesting that higher NETs formation promotes the stabilization of FAM in the circulation, leading to deleterious effects which (in part) may contribute to the symptoms of LC."
An HERV-W ENV transcription in atypical memory B cells linked to #COVID19 evolution & risk for #longCOVID can express the encoded protein from a ribosome readthrough of mRNA from chromosome X
"Results not only confirm HERV-W ENV RNA origin in these patients, but show for the first time how a defective HERV copy can be translated into a complete protein when specific factors make it possible at the ribosome level.”
“Relationship between acute #SARSCoV2 viral clearance with #LongCOVID Symptoms: a cohort study”
"our study of adults with mild to moderate infections offers an important lens into the longitudinal course of SARSCoV2 infections occurring outside the clinical setting"
"Our results add to evidence showing an association between delayed viral clearance and long COVID." "We also observed that the association between viral clearance and #longCOVID differed between men and women."
@tomkindlon@longcovid@covid19@auscovid19 I have shared the invitation to the post Covid seminar, in the Swedish Facebook group for long Covid, as well in my normal Facebook flow.
🧵
Physics Girl fundraiser for the Open Medicine Foundation. A day long livestream on Dianna Cowern's YouTube Physics Girl channel was held on Saturday 6th July. Dianna Cowern has very severe Long Covid / ME/CFS and was seen lying in bed while her husband and experts held discussions.
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With an initial goal of $10,000, the event raised over $120,000.
Open Medicine Foundation Canada on X: "In the coming weeks, we'll be sharing how your amazing support will be put into action. Stay tuned to see how we leverage this incredible day of giving to accelerate our research efforts."