"We have shown that 24% of people post-COVID-19 may have very low oxygen levels in the brain and that this hypoxia relates to reduced neurological function and quality of life."
CPET performed in a well matched cohort with and without acute Covid. "Patients with #COVID19 peculiarly showed a high degree of VE inefficiency as signaled by a marked increase in VE/VCO2 slope"
"data strongly suggest an important role of NK cells in orchestrating the pathophysiology of different phases of COVID-19 and of some post-vaccination side effects."
Opinion piece asking why we overlook bad things, "especially in this scientific and technological age, when we’ve never been more capable of understanding and addressing them".
Trial by Error by David Tuller: Athlete Oonagh Cousins on the Lightning Process
A conversation with world-class rower Oonagh Cousins who got long Covid and whose story has been told by the BBC.
The BBC also covered her negative experience with the contested alternative treatment Lightning Process which she says is exploiting people.
The Organization for Economic Cooperation & Development has published a paper, The impacts of #longCOVID across OECD countries, which looks the burden of Long #Covid including how it may impact productivity & the labour force.
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"The economic and social welfare costs of #longCOVID are dramatic: Even excluding the direct costs of health care, long #COVID is likely costing OECD countries as much as $864 billion - $1.04 trillion USD per year due to reductions in quality of life and labour force participation."
NIH Director Monica Bertagnolli ( @NIHDirector ) comments last week at the NIH ACD (Advisory Committee to the Director) Meeting on Long COVID & RECOVER
"Long Covid and similar energy-limiting illnesses cause a range of health problems which result in long-term sickness absence and long-term unemployment in an era of workforce shortage."
"The aim of this meta-analysis is to describe objective cognitive impairment in individuals with non-severe (mild or moderate) #SARSCoV2 cases in the post-acute stage of infection”
"Significantly increased Cho concentrations & decreased NAA/Cho were found in the CCS in the older #postCOVID19 subjects"
"may be related to the microstructural reorganization in the corpus callosum (also reported in diffusion measurements) rather than increased membrane turnover"
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"SARS-CoV-2 provokes persistent long-term brain metabolic changes on brain FDG PET in the selected population of patients with prolonged long COVID symptoms, without progressive worsening of the hypometabolisms."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
“Although studies have suggested many patients with long #COVID experience mental health challenges, we did not find that depressive symptoms prior to #SARSCoV2 infection were a major risk factor for long COVID”
111,816 children in England & Scotland are estimated to have Long Covid. Toby & his family describe the harsh reality & impact of this disease. Dr Binita Kane says the NHS is not keeping up with the massive challenge Long #Covid represents. The article also mentions reinfection as an elephant in the room.