“In a recent piece Betsy Ladyzhets [from The Sick Times] reports about problems with RECOVER based on documents obtained through the Freedom of Information Act. We talked the other day about her findings.”
Persistent symptoms & clinical findings in adults with post-acute sequelae of #COVID19 / #postCOVID19 syndrome in the second year after acute infection: population-based, nested case-control study
2/
"This nested population-based case-control study demonstrates the majority of PCS cases do not recover in the second year of their illness, with patterns of reported symptoms remaining essentially similar, nonspecific & dominated by fatigue, exercise intolerance & cognitive complaints”
"We report on a patient suffering from fatigue, post exertional malaise, pain & neurological symptoms as a consequence of the second #CoVID infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood”
"Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities & acute #COVID19 severity"
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
"Nine observational studies containing 866,066 patients were included, in which nirmatrelvir-ritonavir and molnupiravir were evaluated in eight and two studies respectively, with both drugs evaluated in one study. Pair-wise meta-analysis showed that early oral antiviral drugs reduced PCC risk (RR 0.77, 95% CI 0.68–0.88)."
"In this study we clustered the transcriptome of #longCOVID patients into two distinct clusters & showed differences in innate and adaptive immune activation and pulmonary function between those clusters"
"Out of 350 [hospitalised] participants, 148 respondents (42.3%) recovered after 1 year of illness and 202 (57.7%) were still experiencing symptoms at the time of survey completion."
2/
"While pacing and energy conservation was a necessary strategy, participants also spoke of the consequences that pacing had on their ability to work, engage in social activities (having to decline at last minute depending on energy level, uncertainty of crashes).
Pacing sometimes involved prioritization and sacrifice, scaling back their activities to the bare minimum to manage their challenges with daily activities. (contd)"
"(Contd) While pacing was an essential skill for many, it was a constant balancing act , that also came at a cost on their productivity, satisfaction, and overall feelings of fulfillment"
4/
"Participants described tracking health trajectories using wearables and other assistive devices including apps, [t]rackers and wireless activity and heart rate monitors to identify potential triggers and learn limits to inform strategies of pacing"
"A notable feature of episodic disability in the context of Long COVID in this study was PESE or PEM which transcended physical, cognitive and mental-emotional dimensions, highlighting the ability of the framework to encompass critical features of disability experienced in the context of #LongCOVID"
"The results of this randomized clinical trial showed that a 15-day course of NMV/r in a population of patients with #PASC was generally safe but did not demonstrate a significant benefit for improving select PASC symptoms in a mostly vaccinated cohort with protracted symptom duration"
4/
"Frequencies of new onset symptoms (in #PostCovid)
Among participants with #LongCOVID, the most common symptoms were post-exertional malaise (87%), fatigue (85%), brain fog (64%), dizziness or lightheadedness (62%), GI (59%), & palpitations (57%)."