(From 2022)
Psychological outcomes of #COVID19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress
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"we determined that the metabolites of the kynurenine pathway, specifically KYN, TRP, 3-HK, and the KYN/TRP ratio, have a strong relationship with the symptoms of depression and anxiety that emerge in post-COVID-19 individuals”
Review article. "The sustained activation of the KP [kynurenine pathway], associated with cognitive impairments & chronic fatigue, underscores the potential of KP as a therapeutic target & as a possible biomarker for #longCOVID in future studies”
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"Remarkably, IgG transfer from the two subgroups, which are characterized by higher plasma levels of neuronal proteins and leukocyte activation markers, induced pronounced and persistent sensory hypersensitivity with distinct kinetics. Conversely, IgG transfer from the third subgroup, which are characterized by enriched skeletal and cardiac muscle proteome profiles, reduced locomotor activity in mice without affecting their motor coordination"
Long #Covid Support:
Research Involvement Consultancy
"We make it easy to involve people with #LongCovid in your research and help ensure your study is relevant, robust and keeps the patient voice at the centre."
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"Our research advisers are all people with Long Covid who are trained in Patient Involvement in Research and have practical experience of being involved in various studies. Book a slot in one of our regular scheduled online advice sessions."
"Interestingly, several symptoms characterizing Long-COVID19 mirror the Postural Orthostatic Tachycardia Syndrome [POTS] that represents the most common form of dysautonomia causing orthostatic intolerance …
The autonomic symptoms reported after SARS-CoV-2 infection are often underestimated by patients and unrecognized by treating physicians."
Blood brain barrier disruption and glutamatergic excitotoxicity in post-acute sequelae of #SARSCOV2 infection cognitive impairment: potential biomarkers & a window into pathogenesis
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"We have undertaken a comprehensive proof-of-concept prospective case–control study to investigate parallel changes in blood brain barrier permeability, neurochemicals, & white matter microstructure changes in #PASC CI [cognitive impairment] patients"
"(Contd) In line with this assumed chronicity, 85% of patients reporting complaints two months after COVID-19 still reported symptoms one year after their symptom onset"
"we applied the advanced imaging technique [Diffusion Microstructure Imaging] to uncover microstructural changes after #COVID19 infection, with the observation of different patterns in a cohort of patients with and without PCC [Post-COVID-condition]"
The Australian ME/CFS & #LongCOVID (AusME) Registry is an online study of individuals aged 12yrs+ with ME/CFS and Long #COVID, as well as healthy volunteers
"U.S. is turning its back on long COVID. We'll pay the price if we don't act."
"There is a hidden public health crisis in America that we can no longer ignore. And that is the crisis of long COVID-19
… about 16 million people throughout our country have long COVID-19. It affects people of all ages and from all backgrounds. And we don’t know why."