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"Frequencies of new onset symptoms (in #PostCovid)
Among participants with #LongCOVID, the most common symptoms were post-exertional malaise (87%), fatigue (85%), brain fog (64%), dizziness or lightheadedness (62%), GI (59%), & palpitations (57%)."
on a New York Times article on a new, major National Academies report, "Long-Term Health Effects of #COVID19: Disability & Function Following #SARSCoV2 Infection"
Extract from comments by Dr Binita Kane in this popular Guardian article today:
"‘I could bench-press 100kg. Now, I can’t walk’: Lucy’s life with #longCovid ."
"Before the pandemic, Lucy Keighley ran a gym, worked as a personal trainer and went on gruelling, exhilarating runs. But after three and a half years of illness, she isn’t sure she will ever recover"
"Experiences of stigma and discrimination resulted in negative healthcare experiences and mistrust in healthcare, creating barriers to help-seeking. (contd)”
"The results revealed significant differences in the neurophysiological parameters of P300 & beta band rhythms in subjects affected by cognitive fog, and these alterations persist even 8 months after recovery from #Covid19"
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“People are developing new-onset disease as the result of an infection that they had 3 years ago,” says Ziyad Al-Aly, “It challenges the notion that these viruses are sort of self-contained or that after the acute phase, they become inconsequential.”
"And cumulatively, at three years, #longCOVID results in 91 disability-adjusted life years (DALY) per 1,000 people—DALYs being a measure of years lost to poor health or premature death. That is a higher incidence than either heart disease or cancer."
"Risks for post-acute sequelae declined over the years, but substantial residual risk remained in the third year, leading to 252.8 sequelae per 1,000 persons& 90.0 DALYs per 1,000 persons”
Association between acquiring SARS-CoV-2 during pregnancy and post-acute sequelae of #SARSCoV2 infection: RECOVER electronic health record cohort analysis
"SARS-CoV-2 infection acquired during pregnancy was associated with lower risk of development of #PASC at 30–180 days after incident SARS-CoV-2 infection in this nationally representative sample”
(From 2022)
Psychological outcomes of #COVID19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress
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"we determined that the metabolites of the kynurenine pathway, specifically KYN, TRP, 3-HK, and the KYN/TRP ratio, have a strong relationship with the symptoms of depression and anxiety that emerge in post-COVID-19 individuals”
Review article. "The sustained activation of the KP [kynurenine pathway], associated with cognitive impairments & chronic fatigue, underscores the potential of KP as a therapeutic target & as a possible biomarker for #longCOVID in future studies”
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"Remarkably, IgG transfer from the two subgroups, which are characterized by higher plasma levels of neuronal proteins and leukocyte activation markers, induced pronounced and persistent sensory hypersensitivity with distinct kinetics. Conversely, IgG transfer from the third subgroup, which are characterized by enriched skeletal and cardiac muscle proteome profiles, reduced locomotor activity in mice without affecting their motor coordination"
Long #Covid Support:
Research Involvement Consultancy
"We make it easy to involve people with #LongCovid in your research and help ensure your study is relevant, robust and keeps the patient voice at the centre."
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"Our research advisers are all people with Long Covid who are trained in Patient Involvement in Research and have practical experience of being involved in various studies. Book a slot in one of our regular scheduled online advice sessions."
"Interestingly, several symptoms characterizing Long-COVID19 mirror the Postural Orthostatic Tachycardia Syndrome [POTS] that represents the most common form of dysautonomia causing orthostatic intolerance …
The autonomic symptoms reported after SARS-CoV-2 infection are often underestimated by patients and unrecognized by treating physicians."
"The parents try to navigate in an unfamiliar world, searching for someone to believe in them and their child, and describe the relief when their child's condition is confirmed. The findings also demonstrate the depth of suffering, not only for the child but also for the whole family."