"Passive transfer of IgG from patients to mice led to increased sensitivity & pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance & coordination, reflecting donor-reported dizziness"
"We have shown that 24% of people post-COVID-19 may have very low oxygen levels in the brain and that this hypoxia relates to reduced neurological function and quality of life."
CPET performed in a well matched cohort with and without acute Covid. "Patients with #COVID19 peculiarly showed a high degree of VE inefficiency as signaled by a marked increase in VE/VCO2 slope"
"data strongly suggest an important role of NK cells in orchestrating the pathophysiology of different phases of COVID-19 and of some post-vaccination side effects."
Opinion piece asking why we overlook bad things, "especially in this scientific and technological age, when we’ve never been more capable of understanding and addressing them".
It’s been a particularly difficult week where I’ve been let down by a number of people who I thought had my back… and the rampant ableism in society is wearing on me.
I revisited one of the first articles I wrote about being disabled & chronically ill… and am saddened that nothing has changed. Things haven’t improved and if anything people are LESS tolerant & more ableist now than a year ago.
It all started when someone said to me “you’ve been sick for years - just die already”. Whenever I think of that statement I find myself wondering if people would have EVER said something like that before Covid. Many may have thought it - but would they verbalize it?
The pandemic is fueling hatred of disabled and chronically ill people to the point where they will say the cruelest things without a second thought - and it’s leading nowhere good.
The Organization for Economic Cooperation & Development has published a paper, The impacts of #longCOVID across OECD countries, which looks the burden of Long #Covid including how it may impact productivity & the labour force.
NIH Director Monica Bertagnolli ( @NIHDirector ) comments last week at the NIH ACD (Advisory Committee to the Director) Meeting on Long COVID & RECOVER
"The aim of this meta-analysis is to describe objective cognitive impairment in individuals with non-severe (mild or moderate) #SARSCoV2 cases in the post-acute stage of infection”
"Significantly increased Cho concentrations & decreased NAA/Cho were found in the CCS in the older #postCOVID19 subjects"
"may be related to the microstructural reorganization in the corpus callosum (also reported in diffusion measurements) rather than increased membrane turnover"
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"SARS-CoV-2 provokes persistent long-term brain metabolic changes on brain FDG PET in the selected population of patients with prolonged long COVID symptoms, without progressive worsening of the hypometabolisms."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
“Although studies have suggested many patients with long #COVID experience mental health challenges, we did not find that depressive symptoms prior to #SARSCoV2 infection were a major risk factor for long COVID”
“In a recent piece Betsy Ladyzhets [from The Sick Times] reports about problems with RECOVER based on documents obtained through the Freedom of Information Act. We talked the other day about her findings.”
Persistent symptoms & clinical findings in adults with post-acute sequelae of #COVID19 / #postCOVID19 syndrome in the second year after acute infection: population-based, nested case-control study
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"This nested population-based case-control study demonstrates the majority of PCS cases do not recover in the second year of their illness, with patterns of reported symptoms remaining essentially similar, nonspecific & dominated by fatigue, exercise intolerance & cognitive complaints”