4/
Extract:
“There is little evidence to suggest that poor fitness is the explanation for PEM – the characteristic worsening of symptoms following exertion – which in many cases does not involve physical
activity at all …”
Neurologically triggered PEM can occur without exceeding a heart rate threshold and is not the result of ventilatory anaerobic threshold problems.
Heart rate-based pacing is helpful for PEM triggered by physical activity, not for PEM triggered by cognitive, sensory, or emotional exertion. The only thing that works for my neuro PEM is timers and carefully calibrating the types of activities I do.
Applying for the #NDIS is soul destroying and they keep adding more paperwork and meetings and bullshit just to wear us down.
I submitted my application in April. I’d been working on it for a year. They generally tell you yes or no without 6 weeks. Instead I didn’t get a reply, I was told the application process has changed and they needed more goals and more meetings. First I was told it was optional, now I’m told it isn’t. Which one is it??
I look like this most days and they want more bloody meetings!?
Applying for the #NDIS is soul destroying and they keep adding more paperwork and meetings and bullshit just to wear us down.
I submitted my application in April. I’d been working on it for a year. They generally tell you yes or no without 6 weeks. Instead I didn’t get a reply, I was told the application process has changed and they needed more goals and more meetings. First I was told it was optional, now I’m told it isn’t. Which one is it??
I look like this most days and they want more bloody meetings!?
"In this work, an interventional method is developed to identify & remove the traveling microthrombi using targeted-magnetic microbubbles (TMMBs) & an interventional magnetic catheter”
New pre-print:
Circulating microclots are structurally associated with Neutrophil Extracellular Traps and their amounts are strongly elevated in long COVID patients
"Our study revealed that NETs may be a component of circulating FAM, suggesting that higher NETs formation promotes the stabilization of FAM in the circulation, leading to deleterious effects which (in part) may contribute to the symptoms of LC."
An HERV-W ENV transcription in atypical memory B cells linked to #COVID19 evolution & risk for #longCOVID can express the encoded protein from a ribosome readthrough of mRNA from chromosome X
"Results not only confirm HERV-W ENV RNA origin in these patients, but show for the first time how a defective HERV copy can be translated into a complete protein when specific factors make it possible at the ribosome level.”
"our study establishes that patients with LCS [#LongCovid Syndrome] exhibit lower absolute and relative HRV values compared to controls, with peak VO2max emerging as a significant mediator in this relationship."
"We found people with #longCOVID are using commercial fitness tracking technologies in unanticipated ways to collect data such as heart rate, number of steps and sleep quality”
“(Contd) These technologies were used to understand the enigmatic long COVID illness and manage symptoms through pacing energy through finding correlations between activities and their impact on their self-tracked data."
"We performed whole-body positron emission tomography imaging in a well-characterized cohort of 24 participants at time points ranging from 27 to 910 days after acute SARS-CoV-2 infection using the radiopharmaceutical agent [18 F]F-AraG, a selective tracer that allows for anatomical quantitation of activated T lymphocytes"