"Passive transfer of IgG from patients to mice led to increased sensitivity & pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance & coordination, reflecting donor-reported dizziness"
"data strongly suggest an important role of NK cells in orchestrating the pathophysiology of different phases of COVID-19 and of some post-vaccination side effects."
"Mounting evidence suggests that immunoglobulin transfer from patient donors often induces the respective SBD phenotype in rodents.
Understanding antibody binding epitopes and downstream mechanisms will require substantial research efforts, but treatments to reduce antibody titres can already now be evaluated."
A webpage with a thread of tweets on the paper "Monitoring treatment harm in #MyalgicE / #CFS: A freedom-of-information study of NHS specialist centres in England" from @mecfsskeptic
NIH has "failed to publish any research that furthers our understanding of the underlying cause of long Covid and the vast majority of clinical trials they’ve launched are for drugs that people have already tried and found unhelpful."
"NIH should reevaluate how it allocates funding to diseases and base allocations on objective patient burdens."
@ahimsa_pdx@mecfs@longcovid what they should do is investigate pathology properly and subtype patients. So as to figure out why 10% of patients responded to a particular drug in a particular trial. Instead of wasting millions.
"Long Covid and similar energy-limiting illnesses cause a range of health problems which result in long-term sickness absence and long-term unemployment in an era of workforce shortage."
"(Contd) The variability of the condition and of employer attitudes, severity of impact on daily life and work, and the fluctuating nature of the condition pose the question of how to manage a sustained return to work."
"Utilizing our novel metabolic modeling method, GPMM [Genome-wide knockout analyses], we identified the key metabolic irregularities in patients with ME/CFS and Long COVID, notably the downregulation of the alanine and aspartate metabolism pathway, and the arginine and proline metabolism pathway."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
I am not enough of an expert to be sure, but this sounds to me like alarmist nonsense, a classic example of how on social media, we hear the most extreme hot takes
Lynn Parramore's commends are spot on. Excellent !!
The referenced National Academy paper, as with most of their papers is hamstrung by the narrow charge they were given. ALL Academy papers suffer severely from this.
They were narrowly charged with long COVID. That is needed, but way overly narrow. They are disallowed from exceeding their charge even a little.
Further, it is very much based on economics and production, not on people's health!
I posted this thinking nobody would read it, but it’s doing the rounds online so let’s hope it spills into real life.
(I would have added an intro if I knew but everyone’s posting it with their own.)
It’s like the powers that be were giving us crumbs and now they’ve decided it’s time for the truth to start coming out.
We don’t have leaders or doctors that even know how to deal with these problems. I don’t have any answers with the world as it is other than “wear masks“
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
Comparing risk of post infection erectile dysfunction following SARS #Coronavirus 2 stratified by acute and long #COVID, hospitalization status, and vasopressor administration
"We found that patients with #longCOVID are at a higher risk of being diagnosed with ED than patients with only acute COVID, while there was no significantly increased risk for patients with more severe infection requiring hospitalization or vasopressors"