111,816 children in England & Scotland are estimated to have Long Covid. Toby & his family describe the harsh reality & impact of this disease. Dr Binita Kane says the NHS is not keeping up with the massive challenge Long #Covid represents. The article also mentions reinfection as an elephant in the room.
"We report on a patient suffering from fatigue, post exertional malaise, pain & neurological symptoms as a consequence of the second #CoVID infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood”
"Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities & acute #COVID19 severity"
"In this study we clustered the transcriptome of #longCOVID patients into two distinct clusters & showed differences in innate and adaptive immune activation and pulmonary function between those clusters"
"Out of 350 [hospitalised] participants, 148 respondents (42.3%) recovered after 1 year of illness and 202 (57.7%) were still experiencing symptoms at the time of survey completion."
"The results of this randomized clinical trial showed that a 15-day course of NMV/r in a population of patients with #PASC was generally safe but did not demonstrate a significant benefit for improving select PASC symptoms in a mostly vaccinated cohort with protracted symptom duration"
on a New York Times article on a new, major National Academies report, "Long-Term Health Effects of #COVID19: Disability & Function Following #SARSCoV2 Infection"
"The results revealed significant differences in the neurophysiological parameters of P300 & beta band rhythms in subjects affected by cognitive fog, and these alterations persist even 8 months after recovery from #Covid19"
Association between acquiring SARS-CoV-2 during pregnancy and post-acute sequelae of #SARSCoV2 infection: RECOVER electronic health record cohort analysis
"SARS-CoV-2 infection acquired during pregnancy was associated with lower risk of development of #PASC at 30–180 days after incident SARS-CoV-2 infection in this nationally representative sample”
Review article. "The sustained activation of the KP [kynurenine pathway], associated with cognitive impairments & chronic fatigue, underscores the potential of KP as a therapeutic target & as a possible biomarker for #longCOVID in future studies”