@tomkindlon
Interesting! Great to see a study confirm anecdotal/survey evidence. Though worth noting that the sample size was too small to make any direct call on CFS: only one person had CFS before getting covid.
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Post summarises this paper:
New Publication by Solve Ramsay Grant Researcher Dr. Deborah Duricka Studies Efficacy of Stellate Ganglion Block in Reducing Post-Exertional Malaise and Improving Sleep and Neurological Function
"Welcome to the 107th Emerge Australia Research Digest, where we delve into recent research and media releases shaping our understanding of ME/CFS and #LongCOVID..."
The summaries are also available in audio form at link
“The idea of rehabilitation will have to be completely rethought for this illness” – Qualitative results of an online survey on patients’ experiences with inpatient rehabilitation for #postCOVID19 condition ( #longCOVID )
'(50 %) reported that their state of health deteriorated, mainly because of strength or endurance training'
'learning strategies to avoid deterioration in their state of health due to overexertion, the so-called pacing, should be the core treatment goal for patients affected by PEM.'
"22.5% did not recover by 90 days post infection". "Recovery within 3 months was less likely in women and those with preexisting cardiovascular disease"
"No significant multivariable-adjusted associations [for non-recovery] were observed for age, educational attainment, smoking history, obesity, diabetes, chronic kidney disease, asthma, chronic obstructive pulmonary disease, or elevated depressive symptoms. Results were similar for reinfections"
"Passive transfer of IgG from patients to mice led to increased sensitivity & pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance & coordination, reflecting donor-reported dizziness"
Opinion piece asking why we overlook bad things, "especially in this scientific and technological age, when we’ve never been more capable of understanding and addressing them".
The Organization for Economic Cooperation & Development has published a paper, The impacts of #longCOVID across OECD countries, which looks the burden of Long #Covid including how it may impact productivity & the labour force.
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"The economic and social welfare costs of #longCOVID are dramatic: Even excluding the direct costs of health care, long #COVID is likely costing OECD countries as much as $864 billion - $1.04 trillion USD per year due to reductions in quality of life and labour force participation."
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"We found that PCC* participants with poorer sleep quality had worse cognitive performance in some domains (verbal and visual memory and processing speed), with a moderating effect on quality of life, cognitive reserve, and everyday memory failure."
"Utilizing our novel metabolic modeling method, GPMM [Genome-wide knockout analyses], we identified the key metabolic irregularities in patients with ME/CFS and Long COVID, notably the downregulation of the alanine and aspartate metabolism pathway, and the arginine and proline metabolism pathway."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
Comparing risk of post infection erectile dysfunction following SARS #Coronavirus 2 stratified by acute and long #COVID, hospitalization status, and vasopressor administration
"We found that patients with #longCOVID are at a higher risk of being diagnosed with ED than patients with only acute COVID, while there was no significantly increased risk for patients with more severe infection requiring hospitalization or vasopressors"