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"We found that PCC* participants with poorer sleep quality had worse cognitive performance in some domains (verbal and visual memory and processing speed), with a moderating effect on quality of life, cognitive reserve, and everyday memory failure."
"The aim of this meta-analysis is to describe objective cognitive impairment in individuals with non-severe (mild or moderate) #SARSCoV2 cases in the post-acute stage of infection”
"Significantly increased Cho concentrations & decreased NAA/Cho were found in the CCS in the older #postCOVID19 subjects"
"may be related to the microstructural reorganization in the corpus callosum (also reported in diffusion measurements) rather than increased membrane turnover"
2/
"SARS-CoV-2 provokes persistent long-term brain metabolic changes on brain FDG PET in the selected population of patients with prolonged long COVID symptoms, without progressive worsening of the hypometabolisms."
"our study shows widespread reductions in cerebral blood oxygen levels in PCS that are related to symptoms of daytime dysfunction and cognitive impairment (contd)"
"(Contd) Changes in oxygen metabolism and blood perfusion may serve as an adaptive mechanism to mediate brain vascular damage and/or as a mode of maintaining normal daily functioning."
“Although studies have suggested many patients with long #COVID experience mental health challenges, we did not find that depressive symptoms prior to #SARSCoV2 infection were a major risk factor for long COVID”
111,816 children in England & Scotland are estimated to have Long Covid. Toby & his family describe the harsh reality & impact of this disease. Dr Binita Kane says the NHS is not keeping up with the massive challenge Long #Covid represents. The article also mentions reinfection as an elephant in the room.
Persistent symptoms & clinical findings in adults with post-acute sequelae of #COVID19 / #postCOVID19 syndrome in the second year after acute infection: population-based, nested case-control study
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"This nested population-based case-control study demonstrates the majority of PCS cases do not recover in the second year of their illness, with patterns of reported symptoms remaining essentially similar, nonspecific & dominated by fatigue, exercise intolerance & cognitive complaints”
"Increase in taurine levels during the transition to convalescence were associated with a reduction in adverse events independent of comorbidities & acute #COVID19 severity"
"When stratified by variant epoch, patients with early epoch Long COVID had persistently elevated peripheral pro-inflammatory cytokine levels when compared to later epoch #LongCOVID. (contd)"
"(Contd) Patients with Long COVID have similar clusters of symptoms across epochs, suggesting that the underlying pathology is independent of the peripheral cytokine signature."
The Australian Government is investing nearly $14.5 million into research to improve our understanding of the impacts of #LongCOVID on individuals, the community & the Australian health system.