stoneparchment

stoneparchment , 2 days ago

The fact this has 40 up votes right now makes me feel like lemmy is losing a diverse user base. Like, where are the women to down vote this obviously shitty take?

Let's list some reasons why these women could have done this that aren't "women are sluts for clown daddies":

• he's their boss, and leveraging his insane power over them to make it hard to say no and keep their job
• he's just an extremely powerful man and they're afraid of pissing him off
• they have insecurities, (like the "loser cuck" fallacy!) that they aren't valuable or desirable as partners, and attention from someone as powerful as him feels like affirmation of their value even if they don't like him or he treats them badly
• they understand that, by not resisting his advances, they might be able to provide themselves a link to a financial source that could support them and a child
• he literally sexually harasses, assaults, or rapes them and they don't feel like they can criminally pursue one of the richest men in the world

Like, yeah, some of them might be individuals who have bad taste in men or are shitty people themselves. I'm even certain that some of them are! But damn, can we take the perspective of the woman for one second? It's not a good look to find yourself agreeing with incels on the internet

stoneparchment , 3 days ago

Why post this summary article from an obscure news group when you could have posted the actual report from the former official?

It's written in accessible language, so it's not like it's too technical to understand or anything...

stoneparchment , 4 days ago

Contrary to most of the opinions in this thread, I think this (and the van gogh incident) is a great and appropriate protest.

It causes a knee-jerk reaction to be mad that they are harming a precious piece of history and culture, which is a perfect juxtaposition to how the climate change harms our precious natural resources and will harm ourselves, and

It achieves this without actually causing permanent damage to the subject artifact, and

It is incendiary enough to remain in our public consciousness long enough for it to affect the discourse.

I only wish there was a more direct way to protest the people most responsible for the worst effects (oil executives, politicians, etc.), but the truth is that the "average middle-class Westerner" (most of the people who have access to enjoy these particular cultural relics) is globally "one of the worst offenders". While I firmly believe that individuals have less power to enact change than corporations and policymakers, this protest does achieve the goal of causing reflection within people who have the power to make changes.

stoneparchment , 17 days ago

I LOVE this

stoneparchment , 1 month ago (edited 1 month ago)

Just curious, when you say "those products are still on the shelves", do you mean they're selling product from the lot numbers that were recalled?

You should be able to tell the grocery store employees and have them remove it if they're selling recalled products, but also I wouldn't be surprised if they're only selling products that are no longer part of those recalled lots

Edit: WAIT you said "still not on the shelves", sorry! Ignore my comment lol

stoneparchment , 1 month ago

I feel like this is true if the reader is meant to have the perspective of the person who feels that something is magic (the Hobbits, in the example from your video). However, not all magic in fiction is like this, and sometimes the reader is supposed to mostly have the perspective of Galadriel, or to gain her perspective over time.

An example is Lev Grossman's The Magicians. The reader has the perspective of the Hobbits at first, because that is the perspective of the main character. But the story has themes of "lifting the veil" of magic, and by the end both the main character and the reader have a more similar perspective to Galadriel.

I guess what I mean is, I agree with you and the video's author in large part... but like... to broadly say that magic "should" be used in literature in a certain way ignores how it can be used in different ways to great effect!

stoneparchment , 2 months ago

it is definitely still a problem, the "naturalness" of the finish is irrelevant

even burning wood itself releases compounds that can be harmful (hence why we advise against breathing in smoke)

I second the idea from a separate poster that if you want to burn, seal, and add more burns-- just use a solvent to remove the seal before you do the second set of burns. Or burn it all at once before sealing

stoneparchment , 3 months ago

"if you can't afford to leave, or you or your family have medical needs and can't relocate, or if all your friends and family and social spheres are here, or if your job is context dependent, or if you're undocumented, or if your spouse or family disagrees with your desire to move, or if you're enrolled in in-state college, or if you're elderly and have lived here your whole life, or if you have a farm, or if your ancestral home is nearby, or if you're homeless, or if you have a strong sense of duty to your community, or if you're a military service member, or if you're a kid...

...that's on you!"

edit: also, many marginalized people know and will tell you-- there isn't a place on this earth for people like us with 100% safety from violence

stoneparchment , 4 months ago

Y'all, the article is talking about a media extinction event, referring to the increasing difficulty of obtaining enough funding to remain solvent as a news source and "race to the bottom" as far as advertisement revenue, page views, and subscriptions.

It is not talking about an actual human extinction event, although of course that is a huge blaring concern at the moment.

Why is it being down voted?

stoneparchment , 4 months ago

No, I genuinely don't understand.

Sure, it's hyperbolic to envoke extinction when you're talking more accurately about the collapse of an industry... but like, it's not like the author is passing off the metaphor as literal.

I guess the answer is that people don't like the title? But the article is interesting and thorough. I enjoyed reading it and hearing the perspective of the journalist.

stoneparchment , 4 months ago

So I think I can make the claim that I am an expert in this, at least compared to 95%+ of biological researchers. My research foci include epigenetic and emergent interactions like the ones discussed in the article, and although I am not going to back this up by identifying myself, please believe me when I say I've written some papers on the topic.

The concept of junk DNA is perhaps the problem here. Obviously there are large swaths of our genome that do not encode anything or have instructions for proteins. However, dismissing all non-coding DNA as "junk" is a critical error.

Your telomeres are a great example. They don't contain vital information so much as they serve a specific function-- providing a buffer region to be consumed during replication in place of DNA that does contain vital information. Your cells would work less well without telomeres, so calling them junk is inaccurate.

Other examples of important non-coding regions are enhancer and promoter regions. Papers describing the philosophical developments of stochasticity in cellular function note how enhancers are vital for increasing the likelihood of transcription by making it more likely that specific proteins floating in the cellular matrix interact with each other. Promoter regions are something most biologists understand already, so I won't describe them here (apologies for anyone who needs to go read about them elsewhere!). Some regions also inform the 3D structure of the genome, creating topological associated domains (TADs) that bring regions of interest closer together.

Even the sequences with less obvious non-coding functions often have some emergent effect on cellular function. Transcription occurs in nonsense regions despite no mRNA being created; instead, tiny, transient non-coding RNAs (ncRNAs) are produced. Because RNA can have functional and catalytic properties like proteins, these small RNAs "do jobs" while they exist. The kinds of things they do before being degraded are less defined than the mechanistic models of proteins, but as we understand more stochastic models, we are beginning to understand how they work.

One last type of DNA that we used to consider junk: binding sites for transcription factors, nucleosome remodelers, and other DNA binding proteins. Proteins are getting stuck to DNA all the time, and then doing things while they're stuck there. Sometimes even just being a place where a nucleosome with a epigenetic flag can camp out and direct other cellular processes is enough to invalidate calling that region "junk".

Anyway I'm done giving my spiel but the take home message here is that all DNA causes stochastic effects and almost all of it (likely all and we haven't figured it out yet) serves some function in-context. Calling all DNA that doesn't encode for a protein "junk" is outdated-- if anything, the protein encoding regions are the boring parts.

stoneparchment , 4 months ago

No, because they are anything other than inactive

stoneparchment , 4 months ago

I would encourage you to read the linked Science paper and Dan Nichol's paper, Is the Cell Really a Machine?

You feel that if a codon isn't meant for something, if it doesn't have a purpose-- then it is junk. This is a mindset that is reflective of the machine model of the cell. We used to expect that each protein was bespoke for a function, each transcript necessary.

The whole paradigm shift at hand is this model falls flat, even for coding regions. I think you're actually very spot in here with the prokaryotic DNA or the plant genomes (love me some violets for their weird genomes). Some parts of a genome will rapidly change and appear to serve no real purpose, but the next bite is the important one: even if it seems like there isn't a purpose, like a top-down prescription for functionality, those regions are still doing something while they are present.

For example, some long non-coding regions affect the likelihood that a person will develop Parkinson's disease, or in the case of plants with various polyploidies, the relative expression of their genes won't necessarily change, but the absolute expression may.

Basically, you aren't wrong that these regions dont have a purpose, because no genes have a purpose. The cell isn't a machine.

stoneparchment , 4 months ago

This is a funny comment though, because "junk" DNA is involved with epigenetic regulation and cellular behavior.

"It's there so it must have function", "it's still in the genetic code so it must have been selected for" is the least nuanced take,

"It's there just randomly and therefore is junk", and "evolution does not select for efficiency" is an improvement,

But "it's there and it's doing something despite not having a bespoke, prescribed function" and "evolution is a cascade of emergent effects and random chance, none of our genome is non-functional even though it is random" is the most up to date take

You seem like a biologist, why not go read some of these papers? Like the one I linked by Dan Nichols? Most people don't have the background necessary to understand the language (no shade) but you seem to!

stoneparchment , 4 months ago

Junk DNA is repeating codons, or codons that occur in areas that are outside of the "start/stop" codon triplicate pairs.

Those sequences do things and have effects. In fact, the coding regions are often less functional than the non-coding ones.

They aren't there for structural reasons, all DNA is the same 4 codons linked together over and over, all the different chromosomes are different sizes.

Sometimes they ARE there for structural reasons? Read: enhancers, or CTCF binding sites? Among many other myriad examples of functional noncoding regions? Also, nucleotides =/= codons. There are 64 codons.

All of this DNA is reported when the cells divide, that's the only time those regions between the stops and starts actually come into play. This is very easily proven, we know the structure of the reading proteins down to the molecule (indeed there are starts and stops and triplicate base pairs that design these transcribing proteins).

That's bull. You're out of your depth. A contemporary college molecular biology course would show your examples to the contrary.

The "important" junk DNA that has significance while not being in a "start->stop" zone are the codons that occur before the first start codon on either side of a DNA strand, when DNA is replicated the protein that starts replicating it has to start at 1 end of 1 side of the DNA in order to be able to read it

I feel like a broken record but Enhancers! lncRNAs! siRNAs! Binding sites! Other gene regulatory regions! Epigenetic nucleosome modifications! Chromatin remodeler sites!

except it needs to find the end first, and to make sure it's all the end it "clips" the first 6 (? Maybe more maybe less, it's been decades since I've studied this)

Oh, there's your problem. A lot has changed. You refuse to see the sea change happening around you because it means you're out of date.

Sorry for the wall of text, but there's plenty of examples of blatantly junk DNA, and there are known methods of how it occurs. Anyone who says every codon pair has a purpose has a screw loose and is ignorant to the mechanics of evolution.

I was happy to reply to you and engage pleasantly originally but you are only engaging with people that know less about biology than you do. You are not an expert if you last studied biology decades ago and can't remember the details. You certainly aren't enough of an authority on the subject to question a contemporary article published in Science or the work of other researchers currently in the field.

I really, really encourage you to read these papers thoroughly. You are the target audience-- people who learned the machine model of the cell and who are gripping it so tightly that they are blind to the nuance that we've uncovered. I also encourage you to not write insults about people who disagree with you, especially people with more domain knowledge than you have.

stoneparchment , 4 months ago

When I say "the cell isn't a machine", it is in specific reference to the machine model of the cell, which is a previously established conceptual framework in the field of molecular biology. If you want to understand why that model is falling out of favor today, you're invited to read the article linked by OP and/or the articles I have linked in other comments.

The gist is that the cell is more complicated, flexible, and emergent than any machine has ever been and will be for the foreseeable future, and the idea that we can simply map the functions of each molecule in the cell to get a perfect "circuit diagram" of how everything plays together is defunct.

I don't have time to mess with this thread any more. You can either accept what myself (an expert in this field), the author of this publication (which happens to be one of the most prestigious journals in the world), and others who do this research daily are saying about this, or you can not. Frankly, if you are an expert also, the field, the research, and the truth barely cares about our opinion-- it certainly doesn't care about non-expert opinions on the internet.

stoneparchment , 5 months ago

The article is about how there are a greater number of co-occuring global elections than ever before, such that more than half of humans will be electing leaders this year.

It is not directly making a claim about the importance of the US presidential election this year.

stoneparchment , 9 months ago

This article is garbage but I'm a molecular biologist and the publication they're talking about is really neat.

The "ELI5 to the point of maybe reducing out the truth" way to explain it is that the researchers can add "flags" to proteins associated with immune responses that make cells pick them up and examine them. This is shown to work for allergins (so say, add a flag to peanut protein and the cells can look at it more closely, go "oh nvm this is fine" and stop freaking out about peanuts) as well as autoimmune diseases (where cells mistake other cells from the same body as potential threats).

It's not nearly to a treatment stage, but tbh this is one of the more exciting approaches I've seen, and I do similar research and thus read a lot of papers like this.

There's a lot of evidence that we are entering a biological "golden age" and we will discover a ton of amazing things very soon. It's worrysome that we still have to deal with instability in other parts of life (climate change, wealth inequality, political polarization) that might slow down the process of turning these discoveries into actual treatments we can use to make lives better...

Still, don't doubt everything you read! A lot of cool stuff is coming, the trick is getting it past the red tape