"Passive transfer of IgG from patients to mice led to increased sensitivity & pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance & coordination, reflecting donor-reported dizziness"
"Associations between Long #COVID and challenges related to housing stability and home accessibility highlight the need for systemic changes, financial support, and advocacy."
A new issue of our Patient-Generated Hypotheses Journal is out! It includes hypotheses on mechanisms & treatments for #LongCovid, ME/CFS, & POTS from patients & caregivers with diverse backgrounds, ranging from PhDs to self-taught patient experts
"Post-exertional malaise (PEM) isn’t due to laziness or deconditioning." - Clayton Powers, DPT Do your symptoms worsen when you push yourself beyond your energy threshold? Powers explains what PEM is in this short video: https://youtu.be/UkS6L3Klc00
CPET performed in a well matched cohort with and without acute Covid. "Patients with #COVID19 peculiarly showed a high degree of VE inefficiency as signaled by a marked increase in VE/VCO2 slope"
"data strongly suggest an important role of NK cells in orchestrating the pathophysiology of different phases of COVID-19 and of some post-vaccination side effects."
"Utilizing our novel metabolic modeling method, GPMM [Genome-wide knockout analyses], we identified the key metabolic irregularities in patients with ME/CFS and Long COVID, notably the downregulation of the alanine and aspartate metabolism pathway, and the arginine and proline metabolism pathway."
"Mounting evidence suggests that immunoglobulin transfer from patient donors often induces the respective SBD phenotype in rodents.
Understanding antibody binding epitopes and downstream mechanisms will require substantial research efforts, but treatments to reduce antibody titres can already now be evaluated."