I'll throw out one from my youth that I think would be really good to see updated: Sentinel Worlds I: Future Magic. It was a very early space RPG which was way ahead of it's time. Something like the recent Heat Signature kinda reminds me of it, though it lacks the scope and depth of combat.
The game was particularly notable for a musical score that simulated multiple instruments by swapping between them faster than the human ear could differentiate.
Why... I understand the reasoning for visual feedback, but audio?
I actually didn't know that about the game, I just linked to the articled to provide details. Given the time the game was written, I suspect it was to make the music a bit more complicated. Game "Music" at the time could leave something to be desired. I played a lot of games with just a PC Speaker, which means that all of the sounds were mostly just different beeps. However, we also didn't know any better at the time and just enjoyed it for what it was.
I mean, if I understand it correctly, audio signals are additive so you don't need to do fancy instrument changing. Simply add the sample of different instruments to the audio buffer and those can be played. If someone knows better about acoustic theory then please correct me.