A lot of peers have had a lot to say about the Cass report but I think I said basically everything I have to say about it back in February before it even dropped:
misapplied empiricism cannot answer the question "should someone be allowed to transition", even in the positive
think about how absurd it would be if we demanded that there needed to be studies before you were allowed to be gay, get married, pick a college major, &c.
that's the kind of naive thinking that leads to the worst kind of "rationalism"