More than that, Blade Runner’s lack of big commercial success is why Dune was done as a stand alone film at first that ends unfinished. The studios didn’t trust that Vilkeneuve could make a profitable film. So instead of doing it lord of the rings style, they’ve waited to see the success of each film separately.
And I bet this lack of success influenced some of Villeneuve’s directorial decisions too. The differences in the general portrayal of women seems quite stark and I wouldn’t be surprised if that was somewhat conscious. I also feel like you can see Villeneuve trying not to make the Dune films too long and boring, which was a complaint of blade runner 2049.