Best cities in South America to see on a layover?

I'm able to book up to 4 layovers of ~20-24 hours each in South America and I'm looking for cities that have large regional airports, decent city-to-airport transit infrastructure, and have stuff to do in the evenings and late mornings. Safety is relative but bonus points for places where tourists aren't casually mugged on a routine basis.

Anyone have any suggestions? I'd love to hear them.

Avg ,

Sao Paulo is nice but you'd want to go through Congonhas instead of Guarulhos since the latter is far from city center.

DudeDudenson ,

I live in Argentina and I think you're asking too much for a latin american layover, hell I'd only expect those conditions in Asia

Pixel OP ,

Honestly, that's a fair comment. It might be an ambitious thing to ask.

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