Upvoting, but I do not admin my own instance, so can only block the instance as a personal user, which means e.g. that they can still mass-downvote me if they so choose. :-(
Also I can still view their comments everywhere, I just don't receive a notification from them anymore if someone replies directly to me, and I could replace my individual per-community blocks with the one instance one for them all. It is nowhere close to "eliminating" them altogether, even though it does cut down on the aggravation a lot.
But I know what you mean, and yes I would like that! Do you know of any instances that blocks those big 3 Axis powers? I looked last week among all the most popular ones listed at that fediverse explorer site but could not find a single one that does. Even Kbin.social only blocks 2 of the 3 but not lemmy.ml...