I've been doing it 50 years so at this point I pretty much know what I like. :)
There are certain writers I follow, certain artists I follow, and certain publishers as well.
There are two new independent publishers who I've signed up for all their stuff, Ghost Machine, which had 3 new #1's drop last week, all of which were good, and DSTLRY which has been doing magazine sized books.
Starting this week is a new storyline in the Superman books called "House of Brainiac" which should be pretty good. I don't typically buy the Supes books, but ever since DC soft rebooted their universe last year under "Dawn of DC" they have ALL been really good.
Batman / Dylan Dog was fun, a crossover between Batman and an Italian comic I had never heard of before. Dylan Dog has appeared in English, rarely, but this is my first experience with it. Good read!
As Arcane noted, Bat-Man First Knight - A retelling of the first Batman story with modern art, is also quite good.
Green Lantern #10 - because I'm an old time GL fan. :)
Outsiders #6 - An official/unofficial continuation of an indie book I always liked called "Planetary". This new version just set in the DC universe.
Aliens What If? From Marvel is interesting, written in conjunction with actor Paul Reiser, the premise is Burke from the Aliens film somehow survived. The book goes into "What if?" that had happened.
There's other stuff I'm picking up, mostly out of habit at this point. The current X-Men books are winding down as they are going to re-boot it all again in about 2 months time, around when X-Men 35 comes out.
This last X-Men run from House of X / Powers of X a few years ago was stellar up to a point, then it kind of ran off the rails and hasn't been the same since. :( I'm not sad to see the current run go and hopefully be replaced with something better, but I am an OLD school X-Men fan with a complete run of the original book.