How are you powering the pi itself? Wondering if the wakeup draw from your screen is enough to make it unstable, 4 I believe having higher power drawn than the 3 if you're using the same power supply. Pi isn't oced either?
Quick Edit: I run my v2.4 on a lepotato with oodles of usb attachments (camera, multiple mcus, wifi and a screen. Replacing the mcu connections with a usb-canbus bridge when the heatwave ends) but with it connected directly to a meanwell 5v5a PSU into the gpio header, have never had communication issues to the octopus pro I use. Skr mini on the other printer is connected to a laptop host so it definitely has enough power, did have some odd issues with the skr mini and having an accelerometer connected to the spi header on boot and separately the 24v supply becoming loose that I fixed by crimping ferules onto the supply wires when I added a molex connector to make taking the printer out of its enclosure easier.