MyNameIsRichard , 4 months ago

I created a systemd service by putting the following in /etc/systemd/system/disable-mouse-wakeup.service

[Unit]
Description=Disable Mouse wakeup triggers

[Service]
Type=oneshot
ExecStart=/bin/sh -c "echo XHC0 > /proc/acpi/wakeup"
ExecStop=/bin/sh -c "echo XHC0 > /proc/acpi/wakeup"
RemainAfterExit=yes

[Install] 
WantedBy=multi-user.target

Then I ran sudo systemctl enable --now disable-mouse-wakeup

It works perfectly on my AMD machine.