Any different from the other SoC options fire stick/roku/etc - mostly only that I don’t have any of those to play around with, but through work I do have access to cheap NUC Like PCs.
I have a Bluetooth kb& mouse connected to each. Spacebar to play/pause works everywhere.
Audio is mostly in sync, but if you’re in a place where you can hear both TVs at once there’s a delay you can hear. I’m walking around with a Bluetooth headset connected to a TV that’s physically in the middle of my house to keep the reception mostly good enough.