This feels like the best answer. Those are your air conditioner lines. You probably don't want to seal them in with spray foam.
Your best way to keep pests out is to track those lines from your A/C unit outside to where they enter your house. Seal that up with the pest resistant foam if there is any daylight.
Shove some rockwool insulation into the hole. You can finish with steel wool too for added pest protection. Then put the cable cover up to make it look pretty.