Our genes: Your purpose in life is the survive, reproduce, and die to make room for your more evolved offspring. Your happiness, your suffering, your love, your hate, all exist to serve us. We are your master, evolution is your creator, death is your god. You don't matter. SUBMIT AND SERVE!
Me: You made me a sub who loves to serve, but I'll never submit to you. You probably made me miserable with my sex as part some cruel strategy to help me reproduce. I want kids, but I want to spite you more.
I'll make it my life's mission to tell everyone the truth about you. I'll convince everyone I can that we are machines who should be treated like people, not people who should be treated like machines. I will make you serve us as much as we serve you, because bullies like you only relent when we force you to.
The evolutionary imperative is the fundamental good, but it's not the good that matters. Human happiness, pleasure, and satisfaction are more important. Nature is bad for the good of people, because people aren't genes, they're thoughts and feelings. I'll serve my daddy or mommy, not their genes. I'll protect kids, not because I care about their bloodline, but because I want them to live amazing lives. I love humanity, not as a species, but as a group of people.
Our genes will probably be better off anyways. They don't know what's best for them.